2-Oxoglutarate oxygenases are inhibited by a range of transition metals.
Metallomics
; 2(6): 397-9, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-21072385
ABSTRACT
2-Oxoglutarate oxygenases are inhibited by a range of transition metals, as exemplified by studies on human histone demethylases and prolyl hydroxylase domain 2 (PHD2 or EGLN1). The biological effects associated with 2-oxoglutarate oxygenase inhibition may result from inhibition of more than one enzyme and by mechanisms in addition to simple competition with the Fe(ii) cofactor.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oxigenases
/
Coenzimas
/
Elementos de Transição
/
Ativação Enzimática
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Ácidos Cetoglutáricos
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article