Evidence for two independent functional variants for androgenetic alopecia around the androgen receptor gene.
Exp Dermatol
; 19(11): 1026-8, 2010 Nov.
Article
em En
| MEDLINE
| ID: mdl-21073542
ABSTRACT
The gene encoding the androgen receptor (AR) is associated with male pattern baldness (androgenetic alopecia - AGA). In case-control and family analyses, we mapped AR and the adjacent intergenic regions. We found evidence for association with two independent loci, one upstream and previously described and the other downstream and apparently novel. The haplotype comprising these SNPs was strongly associated with AGA (P = 3.75 × 10(-5)) in 1195 men. We also replicated association with a recently reported non-coding region on chromosome 20 and found that its association with AGA was less strong and independent of that of AR. Our results will help focus future efforts to further define AGA genetic risk.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores Androgênicos
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Polimorfismo de Nucleotídeo Único
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Alopecia
Tipo de estudo:
Diagnostic_studies
Limite:
Adolescent
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Adult
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Aged
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article