CD28 superagonist-induced regulatory T cell expansion ameliorates mesangioproliferative glomerulonephritis in rats.
Clin Exp Nephrol
; 15(1): 50-7, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-21076989
ABSTRACT
BACKGROUND:
Naturally occurring regulatory T cells (Treg) are essential for the prevention of autoimmunity and overshooting immune responses to pathogens; however, the involvement of Treg in mesangioproliferative glomerulonephritis, a major cause of chronic kidney disease, remains unclear. Superagonistic CD28-specific monoclonal antibodies (CD28SA) are highly effective activators of Treg in rats.METHOD:
To confirm our hypothesis that CD28SA reduces the severity of experimental glomerulonephritis, anti-Thy1 nephritis model rats were treated with CD28SA or saline.RESULTS:
CD28SA significantly suppressed the increase in proteinuria and serum creatinine levels. CD28SA-treated nephritic rats exhibited an increase in the infiltration of Treg in the glomeruli accompanied by infiltration of CD163-positive macrophages ("alternatively activated" macrophages). In addition, CD28SA significantly induced interleukin-10 mRNA expression in glomeruli, thereby ameliorating mesangial cell proliferation and extracellular matrix expansion.CONCLUSION:
We established a new therapeutic approach to suppressing progressive glomerulonephritis. The therapeutic value of this approach warrants further attention and preclinical studies.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Ativação Linfocitária
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Glomerulonefrite Membranoproliferativa
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Linfócitos T Reguladores
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Antígenos CD28
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Anticorpos Monoclonais
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article