PIH1D1, a subunit of R2TP complex, inhibits doxorubicin-induced apoptosis.
Biochem Biophys Res Commun
; 403(3-4): 340-4, 2010 Dec 17.
Article
em En
| MEDLINE
| ID: mdl-21078300
ABSTRACT
We have previously reported that the two components of R2TP complex, RNA polymerase II-associated protein 3 (RPAP3), and Reptin, regulate apoptosis. Here we characterize another component of the complex, PIH1 domain containing protein 1 (PIH1D1). PIH1D1 interacts with both RPAP3 and Monad in HEK293 or U2OS cells. PIH1D1 transcripts were abundant in lung, leukocyte, and placenta. The reduction in endogenous PIH1D1 by siRNA enhanced apoptosis and caspase-3 activation induced by doxorubicin in U2OS cells. These results suggest that PIH1D1 may also function as a novel modulator of apoptosis pathway.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Transporte
/
Apoptose
/
DNA Helicases
/
Proteínas Reguladoras de Apoptose
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article