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Inflammasomes and their activation.
Khare, Sonal; Luc, Nancy; Dorfleutner, Andrea; Stehlik, Christian.
Afiliação
  • Khare S; Division of Rheumatology, Department of Medicine and Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Crit Rev Immunol ; 30(5): 463-87, 2010.
Article em En | MEDLINE | ID: mdl-21083527
The innate immune system relies on the recognition of pathogens by pattern recognition receptors as a first line of defense and to initiate the adaptive immune response. Substantial progress has been made in defining the role of Nod (nucleotide-binding oligimerization domain)-like receptors and AIM2 (absent in melanoma 2) as pattern recognition receptors that activate inflammasomes in macrophages. Inflammasomes are protein platforms essential for the activation of inflammatory caspases and subsequent maturation of their pro-inflammatory cytokine substrates and induction of pyroptosis. This paper summarizes recent developments regarding the function of Nod-like receptors in immunity and disease.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Adaptadoras de Sinalização NOD / Inflamação Limite: Animals / Humans Idioma: En Ano de publicação: 2010 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Adaptadoras de Sinalização NOD / Inflamação Limite: Animals / Humans Idioma: En Ano de publicação: 2010 Tipo de documento: Article