Generation Scotland: Donor DNA Databank; A control DNA resource.
BMC Med Genet
; 11: 166, 2010 Nov 23.
Article
em En
| MEDLINE
| ID: mdl-21092308
ABSTRACT
BACKGROUND:
Many medical disorders of public health importance are complex diseases caused by multiple genetic, environmental and lifestyle factors. Recent technological advances have made it possible to analyse the genetic variants that predispose to complex diseases. Reliable detection of these variants requires genome-wide association studies in sufficiently large numbers of cases and controls. This approach is often hampered by difficulties in collecting appropriate control samples. The Generation Scotland Donor DNA Databank (GS3D) aims to help solve this problem by providing a resource of control DNA and plasma samples accessible for research.METHODS:
GS3D participants were recruited from volunteer blood donors attending Scottish National Blood Transfusion Service (SNBTS) clinics across Scotland. All participants gave full written consent for GS3D to take spare blood from their normal donation. Participants also supplied demographic data by completing a short questionnaire.RESULTS:
Over five thousand complete sets of samples, data and consent forms were collected. DNA and plasma were extracted and stored. The data and samples were unlinked from their original SNBTS identifier number. The plasma, DNA and demographic data are available for research. New data obtained from analysis of the resource will be fed back to GS3D and will be made available to other researchers as appropriate.CONCLUSIONS:
Recruitment of blood donors is an efficient and cost-effective way of collecting thousands of control samples. Because the collection is large, subsets of controls can be selected, based on age range, gender, and ethnic or geographic origin. The GS3D resource should reduce time and expense for investigators who would otherwise have had to recruit their own controls.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Grupos Controle
/
Bases de Dados de Ácidos Nucleicos
Tipo de estudo:
Prognostic_studies
Limite:
Humans
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article