A novel 16k micro-nail CMOS-chip for in-vitro single-cell recording, stimulation and impedance measurements.
Annu Int Conf IEEE Eng Med Biol Soc
; 2010: 2726-9, 2010.
Article
em En
| MEDLINE
| ID: mdl-21096209
ABSTRACT
In neurophysiological and pharmaceutical research, parallel and individual access to a dense population of in-vitro cultured neurons is a key feature for analyzing networks of neurons. This paper presents a 0.18µm CMOS chip containing a dense array of micro-nail electrodes, a 128×128 sensor/actuator matrix with in-situ differential amplification circuits, pico-Ampere current stimulation, and impedance measurement circuits. Measurements on packaged chips show successful impedance measurements matching the simulation model and electrical recordings of in-vitro cultured cardiomyocytes, correlated with recorded changes in intra-cellular calcium concentrations. This system is a first step towards a high-throughput neuron/chip interface.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Impedância Elétrica
/
Microeletrodos
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article