Expression and role of p75 interleukin 2 receptor on human monocytes.
J Exp Med
; 171(5): 1821-6, 1990 May 01.
Article
em En
| MEDLINE
| ID: mdl-2110244
ABSTRACT
We investigated the expression of IL-2R subunits in human monocytes using the TU27 mAb, which recognizes the p75 chain, and anti-Tac mAb, which recognizes the p55 moiety of the IL-2R. We found that p75 but not p55 is constitutively expressed in more than 90% of fresh human monocytes. Antibody to p75, but not to p55, inhibited the activation of monocytes to a cytotoxic stage induced by IL-2 but did not block IFN-gamma-induced cytotoxicity. Our data demonstrate that the p75 chain is expressed on human monocytes and is involved in the activation of monocytes by IL-2.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos
/
Monócitos
/
Receptores de Interleucina-2
Limite:
Humans
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article