Asymmetric cell division: recent developments and their implications for tumour biology.
Nat Rev Mol Cell Biol
; 11(12): 849-60, 2010 Dec.
Article
em En
| MEDLINE
| ID: mdl-21102610
ABSTRACT
The ability of cells to divide asymmetrically is essential for generating diverse cell types during development. The past 10 years have seen tremendous progress in our understanding of this important biological process. We have learned that localized phosphorylation events are responsible for the asymmetric segregation of cell fate determinants in mitosis and that centrosomes and microtubules play important parts in this process. The relevance of asymmetric cell division for stem cell biology has added a new dimension to the field, and exciting connections between asymmetric cell division and tumorigenesis have begun to emerge.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Divisão Celular
/
Biologia Celular
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Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article