Do beta-lactam antibiotics permeabilize the outer membrane of gram-negative bacteria? An electrochemical investigation.
FEMS Microbiol Lett
; 56(3): 313-7, 1990 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-2111261
ABSTRACT
The effects of cefotaxime and EDTA on the reducing activity of Escherichia coli and Staphylococcus aureus cultures growing in the presence of lipoic acid (LA) were investigated by potential-time measurements. The potentiometric responses of E. coli cultures exposed to EDTA indicated enhanced transmembrane transport of LA as a consequence of the outer membrane permeabilization by the chelator, whereas EDTA exerted no effect on the reducing activity of S. aureus cultures. In the same way, cefotaxime stimulated the reducing activity of E. coli, but not that of S. aureus. These results suggest that cefotaxime, and, more generally, a great variety of beta-lactam antibiotics, are able to permeabilize the outer membrane of Gram-negative bacteria.
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Base de dados:
MEDLINE
Assunto principal:
Staphylococcus aureus
/
Permeabilidade da Membrana Celular
/
Escherichia coli
/
Antibacterianos
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article