Insulin resistance and coronary flow velocity reserve in patients with autosomal dominant polycystic kidney disease.
Intern Med J
; 42(2): 146-53, 2012 Feb.
Article
em En
| MEDLINE
| ID: mdl-21118411
ABSTRACT
BACKGROUND:
Cardiovascular problems are a major cause of morbidity and mortality in patients with autosomal dominant polycystic kidney disease (ADPKD).AIM:
The aim of this study was to investigate coronary flow velocity reserve (CFVR) as a marker of endothelial dysfunction, carotid intima media thickness (CIMT) as a marker of subclinical organ damage and insulin resistance (IR) as a cardiovascular risk factor in patients with ADPKD.METHODS:
Twenty-two normotensive ADPKD patients with well-preserved renal function and 19 healthy subjects were included in the study. Creatinine clearances were calculated by the Cockcroft-Gault formula. The homeostasis model of IR (HOMA-IR) was used to measure IR. CIMT was measured by high-resolution vascular ultrasound. CFVR was calculated as the ratio of hyperaemic to baseline diastolic peak velocities by echocardiography.RESULTS:
There was no significant difference between the two groups regarding age, gender, body mass index, systolic and diastolic blood pressures, cholesterol and triglyceride levels. However, CIMT and HOMA-IR were significantly increased and CFVR was significantly decreased in patients with ADPKD compared with healthy subjects.CONCLUSIONS:
The findings of decreased CFVR, increased CIMT and increased IR suggest that cardiovascular risk is elevated even in the early stages of ADPKD.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Velocidade do Fluxo Sanguíneo
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Resistência à Insulina
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Artérias Carótidas
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Rim Policístico Autossômico Dominante
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Espessura Intima-Media Carotídea
Tipo de estudo:
Clinical_trials
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Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article