Synthetic and mechanistic pathways of cis and trans-hydroxytamoxifen drug derivatives reacting with Cp*Rh complexes that involve η1-N, η2-N,O, η1-O, and η6 bonding modes, via a novel N-π rearrangement; relative binding affinities and computer docking studies of cis and trans-η6-Cp*Rh-hydroxytamoxifen complexes at the estrogen, ERα and ERß receptors, and growth inhibition to breast cancer cells.
Inorg Chem
; 50(1): 271-84, 2011 Jan 03.
Article
em En
| MEDLINE
| ID: mdl-21121684
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
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Tamoxifeno
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Antineoplásicos Hormonais
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Receptor alfa de Estrogênio
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Receptor beta de Estrogênio
Limite:
Female
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Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article