Relationship between type 1 diabetes and atopic diseases in a twin population.
Allergy
; 66(5): 645-7, 2011 May.
Article
em En
| MEDLINE
| ID: mdl-21121932
ABSTRACT
AIM:
To study the association between type 1 diabetes and atopic diseases in a twin population.METHODS:
We performed record linkage between questionnaire-defined atopic dermatitis, asthma and hay fever, and hospital discharge diagnoses of type 1 diabetes in 54,530 Danish twins, 3-71 years of age.RESULTS:
The age- and sex-adjusted risk of atopic dermatitis was decreased in subjects with type 1 diabetes compared with nondiabetic subjects, (2.1%vs 9.9%), odds ratio (OR)= 0.23 (0.07-0.71), P = 0.011, whereas asthma and hay fever were not significantly associated with type 1 diabetes. Within twin pairs discordant for type 1 diabetes, the diabetic twin had a lower risk of atopic dermatitis relative to the nondiabetic co-twin. Genetic factors for atopic dermatitis and type 1 diabetes were negatively correlated (r = -0.30), P = 0.0009.CONCLUSIONS:
These findings substantiate the Th1 vs Th2 cell dichotomy for type 1 diabetes and atopic dermatitis, and indicate an inverse association between genetic factors for these disorders.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dermatite Atópica
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Diabetes Mellitus Tipo 1
Tipo de estudo:
Etiology_studies
Limite:
Adolescent
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Adult
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Aged
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Child
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Child, preschool
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article