The plasmin-antiplasmin system: structural and functional aspects.
Cell Mol Life Sci
; 68(5): 785-801, 2011 Mar.
Article
em En
| MEDLINE
| ID: mdl-21136135
ABSTRACT
The plasmin-antiplasmin system plays a key role in blood coagulation and fibrinolysis. Plasmin and α(2)-antiplasmin are primarily responsible for a controlled and regulated dissolution of the fibrin polymers into soluble fragments. However, besides plasmin(ogen) and α(2)-antiplasmin the system contains a series of specific activators and inhibitors. The main physiological activators of plasminogen are tissue-type plasminogen activator, which is mainly involved in the dissolution of the fibrin polymers by plasmin, and urokinase-type plasminogen activator, which is primarily responsible for the generation of plasmin activity in the intercellular space. Both activators are multidomain serine proteases. Besides the main physiological inhibitor α(2)-antiplasmin, the plasmin-antiplasmin system is also regulated by the general protease inhibitor α(2)-macroglobulin, a member of the protease inhibitor I39 family. The activity of the plasminogen activators is primarily regulated by the plasminogen activator inhibitors 1 and 2, members of the serine protease inhibitor superfamily.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Plasminogênio
/
Antifibrinolíticos
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article