TP53 codon 72 polymorphism and colorectal cancer susceptibility: a meta-analysis.

ABSTRACT

Colorectal cancer constitutes a significant proportion of the global burden of cancer morbidity and mortality. A number of studies have been conducted to explore whether TP53 codon 72 polymorphism is associated with colorectal cancer susceptibility. However, controversial results were obtained. In order to derive a more precise estimation of the relationship, we systematically searched Medline, Google scholar, and Ovid database for studies reported before May 2010. A total of 3603 colorectal cancer cases and 5524 controls were included. TP53 codon 72 polymorphism was not associated with colorectal cancer risk in all genetic models (for dominant model OR = 0.99, 95% CI 0.86-1.15; for recessive model OR = 1.00, 95% CI 0.81-1.23; for Arg/Pro vs. Arg/Arg OR = 1.00, 95% CI 0.87-1.15; for Pro/Pro vs. Arg/Arg OR = 0.97, 95% CI 0.76-1.25). In the subgroup analyses by ethnic groups and sources of controls, no significant associations were found in all models. Taken together, this meta-analysis suggested that the biologically usefulness of TP53 codon 72 polymorphism as a selection marker in colorectal cancer susceptibility may be very limited.