Toward clinical proteomics on a next-generation sequencing platform.
Anal Chem
; 83(3): 666-70, 2011 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-21142014
ABSTRACT
We report the first next generation sequencing (NGS) application to identify and quantify proteins. Customization of protein specific aptamers enabled direct conversion of serum protein information into NGS read outs. The intrinsic ability of aptamer sequencing to highly multiplex protein detection and quantification, together with the prospect of DNA sequencing further evolving into a commodity technology, could constitute the core of a novel, universal diagnostics paradigm.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Análise de Sequência de DNA
/
Proteômica
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article