Lipid raft proteome reveals that oxidative phosphorylation system is associated with the plasma membrane.
Expert Rev Proteomics
; 7(6): 849-66, 2010 Dec.
Article
em En
| MEDLINE
| ID: mdl-21142887
ABSTRACT
Although accumulating proteomic analyses have supported the fact that mitochondrial oxidative phosphorylation (OXPHOS) complexes are localized in lipid rafts, which mediate cell signaling, immune response and host-pathogen interactions, there has been no in-depth study of the physiological functions of lipid-raft OXPHOS complexes. Here, we show that many subunits of OXPHOS complexes were identified from the lipid rafts of human adipocytes, C2C12 myotubes, Jurkat cells and surface biotin-labeled Jurkat cells via shotgun proteomic analysis. We discuss the findings of OXPHOS complexes in lipid rafts, the role of the surface ATP synthase complex as a receptor for various ligands and extracellular superoxide generation by plasma membrane oxidative phosphorylation complexes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Membrana Celular
/
Proteoma
/
Microdomínios da Membrana
/
Complexos Multienzimáticos
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article