Divergence of duplicate POMC genes in gilthead sea bream Sparus auratus.
Gen Comp Endocrinol
; 173(3): 396-404, 2011 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-21147111
Proopiomelanocorticotrophin (POMC) in vertebrates is produced in the pituitary gland and undergoes post-translational processing to give rise to a range of biologically active peptides. Teleosts possess 2-3 different POMC transcripts which have been proposed to have originated from a whole or partial genome duplication. In the present study 2 transcripts of gilthead sea bream POMC (sbPOMC-α1 and α2) were cloned and characterised. sbPOMC-α1 is expressed principally in the melanotroph cells of the pars intermedia (PI) and sbPOMC-α2 is expressed in the corticotroph cells of the rostral pars distalis and probably also in the PI. The 2 sbPOMC transcripts have a differential tissue distribution in extra-pituitary sites. An appraisal of POMC evolution indicates sbPOMCs belong to one of the two main clades that exist in teleosts and that overall a non conservative process of gene loss occurred in this infraclass.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pró-Opiomelanocortina
/
Duplicação Gênica
/
Dourada
/
Proteínas de Peixes
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article