Myc-nick: the force behind c-Myc.
Sci Signal
; 3(152): pe49, 2010 Dec 14.
Article
em En
| MEDLINE
| ID: mdl-21156935
ABSTRACT
In the field of molecular oncology, the Myc basic helix-loop-helix family of transcription factors has been extensively studied. The Myc proto-oncogene c-Myc binds DNA, activates or represses gene transcription, and consequently affects cellular proliferation. However, emerging evidence presents the existence of c-Myc variants that lack transcriptional activity. A cytoplasmic variant of c-Myc called "Myc-nick," which arises from calpain-mediated cleavage of c-Myc, assists in stable microtubule assembly. Furthermore, Myc-nick promotes MyoD-mediated myogenic differentiation, thus antagonizing its precursor. These results provide exciting new opportunities in formulating molecular approaches for treatment of cancer and in our understanding of cell differentiation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Calpaína
/
Proteínas Proto-Oncogênicas c-myc
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article