[Association of lipoprotein lipase gene Hind III and S447X polymorphisms in metabolic syndrome patients among Kazakh and Han ethnics from Xinjiang].

ABSTRACT

OBJECTIVE: To investigate the association of lipoprotein lipase gene Hind III and S447X polymorphisms with metabolic syndrome among Kazakh and Han ethnicities in Xinjiang. METHODS: PCR-RFLP was used to detect 802 subjects' lipoprotein lipase Hind III and S447X genotypes (including 201 controls and 200 metabolic syndrome patients in Kazakh and Han ethnicities, respectively). RESULTS: (1) Frequencies of H+H-/H-H- genotype (32.50% vs. 47.76%), H- allele (18.00% vs. 28.86%), SX/XX genotype (8.00% vs. 22.39%) and X allele (4.00% vs. 12.44%) for metabolic syndrome in Han ethnicity were all significantly lower than those in controls (P < 0.01). (2) The frequencies of H+H-/H-H- genotype (33.50% vs. 46.80%), H- allele (22.00% vs. 28.60%), SX/XX genotype (10.50% vs. 22.90%) and X allele (5.50% vs. 12.44%) in patients with metabolic syndrome in Kazakh were all significantly lower than those for controls (P < 0.01). (3) The frequencies of lipoprotein lipase gene Hind III and S447X genotypes and alleles in Kazakh were not significantly different from Han (all P > 0.05). (4) The levels of waist circumference, systolic blood pressure, diastolic blood pressure, triglyceride and FPG in H+H-/H-H- and SX/XX genotype were significantly lower than those in H+H+ and SS genotype. HDL-C was significantly higher than that in H+H+ and SS genotype (P < 0.05). (5) The frequencies of H+H+ and SS genotype increased along with the increase in number of metabolic syndrome component. CONCLUSION: The lipoprotein lipase gene Hind III and S447X polymorphisms were associated with metabolic syndrome risk in Kazakh, and H+H-/H-H- genotype, H- allele, SX/XX genotype and X allele might have served as protective factors of metabolic syndrome. H+H-/H-H- and SX/XX genotype seemed to have had beneficial effects for all the metabolic syndrome components, and the frequencies of H+H+ and SS genotype were increasing along with the increase of number in the metabolic syndrome components.