Genetic characterization of Bulgarian rotavirus isolates and detection of rotavirus variants: challenges for the rotavirus vaccine program?
J Med Virol
; 83(2): 348-56, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-21181933
ABSTRACT
Annually 20-70% of all hospital admissions and 20% of fatal diarrhea cases among children less than 5 years of age occur due to severe rotavirus diarrhea. Universal immunization is the major strategy aimed at controlling rotavirus infection. The main objective of the present study was to elucidate the evolutionary relationships of the most common rotavirus strains co-circulating in Bulgaria. The sequence and phylogenetic analysis revealed strain diversity and circulation of different rotavirus variants belonging to a single genotype. A mutated G4P[8] strain with the insertion of an asparagine residue in position 76; G2, G9, and G1 variants with amino acid substitutions in the antigenic regions A, B, and/or C were all identified in this study in the absence of an immunization program. Rotavirus strain surveillance in both the pre- and post-vaccine eras is of increasing importance in order to assess the effectiveness of the rotavirus vaccines for protection against disease associated with a diverse population of rotavirus strains.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções por Rotavirus
/
Programas de Imunização
/
Rotavirus
/
Vacinas contra Rotavirus
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Child
/
Child, preschool
/
Humans
/
Infant
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article