Electrical synapses control hippocampal contributions to fear learning and memory.
Science
; 331(6013): 87-91, 2011 Jan 07.
Article
em En
| MEDLINE
| ID: mdl-21212357
ABSTRACT
The role of electrical synapses in synchronizing neuronal assemblies in the adult mammalian brain is well documented. However, their role in learning and memory processes remains unclear. By combining Pavlovian fear conditioning, activity-dependent immediate early gene expression, and in vivo electrophysiology, we discovered that blocking neuronal gap junctions within the dorsal hippocampus impaired context-dependent fear learning, memory, and extinction. Theta rhythms in freely moving rats were also disrupted. Our results show that gap junction-mediated neuronal transmission is a prominent feature underlying emotional memories.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sinapses Elétricas
/
Medo
/
Hipocampo
/
Aprendizagem
/
Memória
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article