Flavonoid glycosides from Chromolaena odorata leaves and their in vitro cytotoxic activity.
Chem Pharm Bull (Tokyo)
; 59(1): 129-31, 2011.
Article
em En
| MEDLINE
| ID: mdl-21212562
ABSTRACT
Two new flavonoid glycosides, (1, 2), and eleven known compounds, (3-13), were isolated from from a 70% EtOH extract of the leaves of Chromolaena odorata (Asteraceae). Their structures were elucidated by 1D and 2D NMR spectroscopic interpretation as well as by chemical studies. The newly isolated compounds were tested in vitro for their cytotoxic activities against the LLC and HL-60 cancer cell lines. Compound 1 showed cytotoxicity against LLC and HL-60 cancer cell lines with IC(50) values of 28.2 and 11.6 µM, respectively. Compound 2 exhibited significant cytotoxic activity in the inhibition of HL-60 cancer cell lines with IC(50) value of 10.8 µM.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Flavonoides
/
Chromolaena
/
Glicosídeos
/
Antineoplásicos Fitogênicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article