ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1).
Nat Immunol
; 12(2): 178-85, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-21217760
ABSTRACT
Type 2 helper T cells (T(H)2) are critically involved in allergies and asthma. Here we demonstrate that extracellular matrix protein-1 (ECM1) is highly and selectively expressed in T(H)2 cells. ECM1 deficiency caused impaired T(H)2 responses and reduced allergic airway inflammation in vivo. Functional analysis demonstrated that although the T(H)2 polarization of ECM1-deficient cells was unimpaired, these cells had a defect in migration and were retained in peripheral lymphoid organs. This was associated with reduced expression of KLF2 and S1P(1). We also found that ECM1 could directly bind the interleukin-2 (IL-2) receptor to inhibit IL-2 signaling and activate S1P(1) expression. Our data identify a previously unknown function of ECM1 in regulating T(H)2 cell migration through control of KLF2 and S1P(1) expression.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas da Matriz Extracelular
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Receptores de Retorno de Linfócitos
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Células Th2
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Hipersensibilidade
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Proteínas do Tecido Nervoso
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article