[Distributions of primary nasopharyngeal carcinoma tumor and patterns of skull base erosion detected by magnetic resonance imaging].
Zhonghua Yi Xue Za Zhi
; 90(47): 3347-50, 2010 Dec 21.
Article
em Zh
| MEDLINE
| ID: mdl-21223751
ABSTRACT
OBJECTIVE:
To evaluate the distributions of primary nasopharyngeal carcinoma (NPC) and the patterns of skull base involvement in NPC patients using magnetic resonance imaging (MRI).METHODS:
After the approval of institutional review board and informed consent, 838 consecutive newly-diagnosed and untreated NPC patients were examined by MRI. Their MR images were reviewed by two independent radiologists.RESULTS:
Among all cases, the incidence rates of superior side and post-superior side involvement were 98.57% (826/838) and 98.21% (823/838) respectively. The differences were not significant between these two sides (P > 0.05). Lateral side erosion was demonstrated in 784 (93.56%) cases. Posterior side was involved in 391 (46.66%) cases. The total incidence rate of skull base involvement was 65.51% (549/838). According to the anatomic site, the pathways of skull base involvement were classified into 5 spreading routes anterior; superior; super-lateral; super-anterior and super-posterior. According to the incidence rates and the results of chi-square test, the anatomic sites around the nasopharynx were classified into three groups of risk grades high-risk (≥ 35%), medium-risk (≥ 5% - 35%) and low-risk (< 5%).CONCLUSION:
Skull base involvement of NPC spreads stepwise from proximal site to more distal sites. The area of skull base involvement in NPC is classified into high-grade, medium-grade and lower-grade groups respectively. The high and medium-grade groups are related with T3 stage while the lower-grade group T4 stage. Thus T3 stage should be subdivided into T3a and T3b. These schemes may be useful in a more accurate NPC staging and a delineation of clinical target volume for radiotherapy in NPC patients.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
/
Neoplasias Nasofaríngeas
/
Base do Crânio
Tipo de estudo:
Diagnostic_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Ano de publicação:
2010
Tipo de documento:
Article