Understanding the role of SOX9 in acquired diseases: lessons from development.
Trends Mol Med
; 17(3): 166-74, 2011 Mar.
Article
em En
| MEDLINE
| ID: mdl-21237710
ABSTRACT
The transcription factor SOX9 is crucial for multiple aspects of development. Mutations in SOX9 cause campomelic dysplasia, a haploinsufficiency disorder concordant with the expression profile of SOX9 during embryogenesis. The mechanistic understanding of development has revealed roles for SOX9 in regulating cartilage extracellular matrix (ECM) production and cell proliferation, among others. More recently, it transpires that SOX9 becomes expressed and induces destructive ECM components in organ fibrosis and related disorders. Although commonly absent from the parent cell type, SOX9 is expressed in a wide range of cancers, where it regulates cell proliferation. These data have potential diagnostic, prognostic and therapeutic relevance, suggesting that disease mechanisms might result from re-expressing this developmental transcription factor in ectopic locations.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença
/
Regulação da Expressão Gênica no Desenvolvimento
/
Fatores de Transcrição SOX9
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article