High-risk syndrome for neuromyelitis optica: a descriptive and comparative study.
Mult Scler
; 17(6): 720-4, 2011 Jun.
Article
em En
| MEDLINE
| ID: mdl-21239412
ABSTRACT
BACKGROUND:
Neuromyelitis optica (NMO) frequently begins with a monofocal episode of optic neuritis or myelitis. A concept named high-risk syndrome (HRS) for NMO has been proposed for patients with monofocal episodes and NMO-IgG antibodies.OBJECTIVE:
To describe HRS patients and compare them with NMO patients.METHODS:
We identified 30 patients with HRS 18 with extensive myelitis (HRM) and 12 with optic neuritis (HRON), in a database pooling patients from 25 centres in France. Clinical, laboratory/magnetic resonance imaging (MRI) data and outcome were analysed and compared with a national cohort of 125 NMO patients extracted from the same database.RESULTS:
Mean follow-up was 4.8 years. Mean age at onset was 42.8 years (range 12.4-70) with a femalemale ratio of 0.9. Asymptomatic lesions were report on visual evoked potentials in 4/8 tested HRM patients and on spinal cord MRI in 2/7 HRON patients. Three patients died, two owing to a cervical lesion. HRS and NMO patients had similar clinical/paraclinical data, except for a predominance of men in the HRS group and a later mean age at onset in the HRM subgroup.CONCLUSION:
The description of HRS patients is compatible with a monofocal form of NMO. Asymptomatic lesions could be included in a new set of NMO diagnostic criteria.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neurite Óptica
/
Neuromielite Óptica
/
Mielite
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article