Stability and sterility of diluted enoxaparin under three different storage conditions.
J Paediatr Child Health
; 47(5): 299-301, 2011 May.
Article
em En
| MEDLINE
| ID: mdl-21244553
ABSTRACT
AIM:
This study assessed whether enoxaparin sodium diluted to a concentration of 20 mg/mL for clinical use with 0.9% sodium chloride remained stable and sterile for up to 43 days under three different storage conditions.METHODS:
Enoxaparin dilutions in polypropylene syringes were stored under three different controlled conditions of temperature and light (i) room temperature (22-26°C) under natural light; (ii) room temperature (22-26°C) in the dark; and (iii) controlled refrigeration (2-8°C) in the dark. A weekly assay of anti-Xa and anti-IIa activity was undertaken to determine if the diluted enoxaparin preparations retained anticoagulant activity, thus remaining suitable for clinical application.RESULTS:
Our findings indicate that diluted enoxaparin, when stored under the tested varied conditions of light and temperature, retained greater than or equal to 90% of baseline anticoagulant activity for anti-Xa and anti-IIa effect for up to 43 days.CONCLUSIONS:
The study results are significant for families, in that they suggest that at least a month's supply of enoxaparin could be dispensed at a time, reducing the frequency of patients/families returning for supply and providing a more convenient service for paediatric patients.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Enoxaparina
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Armazenamento de Medicamentos
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Anticoagulantes
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article