Association of a variant in the CHRNA5-A3-B4 gene cluster region to heavy smoking in the Italian population.
Eur J Hum Genet
; 19(5): 593-6, 2011 May.
Article
em En
| MEDLINE
| ID: mdl-21248747
ABSTRACT
Large-scale population studies have established that genetic factors contribute to individual differences in smoking behavior. Linkage and genome-wide association studies have shown many chromosomal regions and genes associated with different smoking behaviors. One study was the association of single-nucleotide polymorphisms (SNPs) in the CHRNA5-A3-B4 gene cluster to nicotine addiction. Here, we report a replication of this association in the Italian population represented by three genetically isolated populations. One, the Val Borbera, is a genetic isolate from North-Western Italy; the Cilento population, is located in South-Western Italy; and the Carlantino village is located in South-Eastern Italy. Owing to their position and their isolation, the three populations have a different environment, different history and genetic structure. The variant A of the rs1051730 SNP was significantly associated with smoking quantity in two populations, Val Borbera and Cilento, no association was found in Carlantino population probably because difference in LD pattern in the variant region.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tabagismo
/
Fumar
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Receptores Nicotínicos
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Polimorfismo de Nucleotídeo Único
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Estudo de Associação Genômica Ampla
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Proteínas do Tecido Nervoso
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article