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Hepatitis C pharmacogenetics: state of the art in 2010.
Afdhal, Nezam H; McHutchison, John G; Zeuzem, Stefan; Mangia, Alessandra; Pawlotsky, Jean-Michel; Murray, Jeffrey S; Shianna, Kevin V; Tanaka, Yasuhito; Thomas, David L; Booth, David R; Goldstein, David B.
Afiliação
  • Afdhal NH; Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA. nafdhal@caregroup.harvard.edu
Hepatology ; 53(1): 336-45, 2011 Jan.
Article em En | MEDLINE | ID: mdl-21254181
ABSTRACT
In 2009, a correlated set of polymorphisms in the region of the interleukin-28B (IL28B) gene were associated with clearance of genotype 1 hepatitis C virus (HCV) in patients treated with pegylated interferon-alfa and ribavirin. The same polymorphisms were subsequently associated with spontaneous clearance of HCV in untreated patients. The link between IL28B genotype and HCV clearance may impact decisions regarding initiation of current therapy, the design and interpretation of clinical studies, the economics of treatment, and the process of regulatory approval for new anti-HCV therapeutic agents.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Interleucinas / Hepacivirus / Hepatite C Crônica Tipo de estudo: Prognostic_studies Limite: Humans País como assunto: America do norte Idioma: En Ano de publicação: 2011 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Interleucinas / Hepacivirus / Hepatite C Crônica Tipo de estudo: Prognostic_studies Limite: Humans País como assunto: America do norte Idioma: En Ano de publicação: 2011 Tipo de documento: Article