Control of NF-κB activity by proteolysis.
Curr Top Microbiol Immunol
; 349: 97-114, 2011.
Article
em En
| MEDLINE
| ID: mdl-21267708
ABSTRACT
NF-κB transcription factors are critical regulators of many biological processes such as innate and adaptive immune responses, inflammation, cell proliferation and programmed cell death. This versatility necessitates a highly complex and tightly coordinated control of the signaling pathways leading to their activation. Here, we review the role of proteolysis in the regulation of NF-κB activity, more specifically the contribution of the well-known ubiquitin-proteasome system and the involvement of proteolytic activity of caspases and calpains.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
NF-kappa B
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article