Fate mapping of IL-17-producing T cells in inflammatory responses.
Nat Immunol
; 12(3): 255-63, 2011 Mar.
Article
em En
| MEDLINE
| ID: mdl-21278737
ABSTRACT
Here we describe a reporter mouse strain designed to map the fate of cells that have activated interleukin 17A (IL-17A). We found that IL-17-producing helper T cells (T(H)17 cells) had distinct plasticity in different inflammatory settings. Chronic inflammatory conditions in experimental autoimmune encephalomyelitis (EAE) caused a switch to alternative cytokines in T(H)17 cells, whereas acute cutaneous infection with Candida albicans did not result in the deviation of T(H)17 cells to the production of alternative cytokines, although IL-17A production was shut off in the course of the infection. During the development of EAE, interferon-γ (IFN-γ) and other proinflammatory cytokines in the spinal cord were produced almost exclusively by cells that had produced IL-17 before their conversion by IL-23 ('ex-T(H)17 cells'). Thus, this model allows the actual functional fate of effector T cells to be related to T(H)17 developmental origin regardless of IL-17 expression.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Interleucina-17
/
Inflamação
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article