Design, synthesis and SAR of a series of 1,3,5-trisubstituted benzenes as thrombin inhibitors.
Bioorg Med Chem Lett
; 21(5): 1536-40, 2011 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-21295467
ABSTRACT
A novel 1,3,5-trisubstituted benzamide thrombin inhibitor template was designed via hybridization of a known aminopyridinoneacetamide and a known 1,3,5-trisubstituted phenyl ether. Optimization of this lead afforded a novel potent series of biaryl 1,3,5-trisubstituted benzenes with excellent functional anticoagulant potency.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Benzeno
/
Trombina
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Desenho de Fármacos
/
Antitrombinas
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article