Sugar-bearing tetraphenylethylene: novel fluorescent probe for studies of carbohydrate-protein interaction based on aggregation-induced emission.
Org Biomol Chem
; 9(7): 2219-26, 2011 Apr 07.
Article
em En
| MEDLINE
| ID: mdl-21298179
ABSTRACT
Neutral sugar-bearing tetraphenylethenes (TPE) are designed and prepared as "turn-on" luminescent sensors for lectins and glycosidases based on aggregation-induced emission. Through aggregation derived from carbohydrate-lectin binding, multivalent mannosyl-bearing TPE shows a good selectivity and sensitivity to Con A by switching on the fluorescence of water-soluble tetraphenylethylene-based glyco-conjugates in aqueous solution. Meanwhile, cellobiosyl-bearing TPE can be used to investigate enzymatic hydrolysis based on emission enhancing by glycosidase-induced aggregation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Carboidratos
/
Etilenos
/
Corantes Fluorescentes
/
Lectinas
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article