Otx genes in neurogenesis of mesencephalic dopaminergic neurons.
Dev Neurobiol
; 71(8): 665-79, 2011 Aug.
Article
em En
| MEDLINE
| ID: mdl-21309083
ABSTRACT
Mesencephalic-diencephalic dopaminergic (mdDA) neurons play a relevant role in the control of movement, behavior, and cognition. Indeed loss and/or abnormal functioning of mdDA neurons are responsible for Parkinson's disease as well as for addictive and psychiatric disorders. In the last years a wealth of information has been provided on gene functions controlling identity, fate, and proliferation of mdDA progenitors. This review will focus on the role exerted by Otx genes in early decisions regulating sequential steps required for the neurogenesis of mesencephalic dopaminergic (mesDA) neurons. In this context, the regulatory network involving Otx functional interactions with signaling molecules and transcription factors required to promote or prevent the development of mesDA neurons will be analyzed in detail.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Mesencéfalo
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Dopamina
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Fatores de Transcrição Otx
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Neurogênese
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Neurônios
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article