Genetic diversity of O-antigen biosynthesis regions in Vibrio cholerae.
Appl Environ Microbiol
; 77(7): 2247-53, 2011 Apr.
Article
em En
| MEDLINE
| ID: mdl-21317260
ABSTRACT
O-antigen biosynthetic (wbf) regions for Vibrio cholerae serogroups O5, O8, and O108 were isolated and sequenced. Sequences were compared to those of other published V. cholerae O-antigen regions. These wbf regions showed a high degree of heterogeneity both in gene content and in gene order. Genes identified frequently showed greater similarities to polysaccharide biosynthesis genes from species other than V. cholerae. Our results demonstrate the plasticity of O-antigen genes in V. cholerae, the diversity of the genetic pool from which they are drawn, and the likelihood that new pandemic serogroups will emerge.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Variação Genética
/
Vibrio cholerae
/
Antígenos O
/
Vias Biossintéticas
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article