Serum amyloid A overrides Treg anergy via monocyte-dependent and Treg-intrinsic, SOCS3-associated pathways.
Blood
; 117(14): 3793-8, 2011 Apr 07.
Article
em En
| MEDLINE
| ID: mdl-21325601
ABSTRACT
The acute phase protein serum amyloid A (SAA) has been well characterized as an indicator of inflammation. Nevertheless, its functions in pro versus anti-inflammatory processes remain obscure. Here we provide unexpected evidences that SAA induces the proliferation of the tolerogenic subset of regulatory T cells (T(reg)). Intriguingly, SAA reverses T(reg) anergy via its interaction with monocytes to activate distinct mitogenic pathways in T(reg) but not effector T cells. This selective responsiveness of T(reg) correlates with their diminished expression of SOCS3 and is antagonized by T(reg)-specific induction of this regulator of cytokine signaling. Collectively, these evidences suggest a novel anti-inflammatory role of SAA in the induction of a micro-environment that supports T(reg) expansion at sites of infection or tissue injury, likely to curb (auto)-inflammatory responses.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteína Amiloide A Sérica
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Monócitos
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Linfócitos T Reguladores
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Anergia Clonal
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Proteínas Supressoras da Sinalização de Citocina
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
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Child
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Humans
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Male
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article