An overview of the current diagnosis and recent developments in neuroendocrine tumours of the gastroenteropancreatic tract: the diagnostic approach.
Neth J Med
; 69(1): 14-20, 2011 Jan.
Article
em En
| MEDLINE
| ID: mdl-21325696
ABSTRACT
Neuroendocrine tumours of the gastroenteropancreatic tract (GEP-NETs) comprise a group of very heterogeneous neoplasms, which are considered 'rare diseases'. Epidemiological studies on the incidence of GEP-NETs worldwide have reported a remarkable increase in the detection of these tumours. In a recent study, based on pathology reports (PALGA) to investigate the incidence of pancreatic and duodenal neuroendocrine tumours in the Netherlands from 1991 until 2009, we also noticed a significant increase in the incidence of these tumours. In particular, the incidence of non-functioning neuroendocrine tumours had significantly increased over this period. Remarkably, a substantial discrepancy was observed between the numbers of neuroendocrine tumours diagnosed in the clinical as opposed to the pathological setting, emphasising that these tumours provide a real diagnostic challenge. To improve the diagnosis of GEP -NET s, we advocate that these complex neoplasms should receive more specialised attention. In this mini-review we provide an overview of the current diagnostic approach to GEP-NETs, and add the recent developments in establishing the diagnosis of these tumours, in order to increase knowledge and awareness of GEP-NETs among clinicians and pathologists. Early detection in order to prevent morbidity from GEP-NETs is advocated.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Tumores Neuroendócrinos
/
Neoplasias Gastrointestinais
Tipo de estudo:
Diagnostic_studies
/
Incidence_studies
/
Prognostic_studies
/
Screening_studies
Limite:
Humans
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article