DENN domain proteins: regulators of Rab GTPases.
J Biol Chem
; 286(16): 13791-800, 2011 Apr 22.
Article
em En
| MEDLINE
| ID: mdl-21330364
ABSTRACT
The DENN domain is a common, evolutionarily ancient, and conserved protein module, yet it has gone largely unstudied; until recently, little was known regarding its functional roles. New studies reveal that various DENN domains interact directly with members of the Rab family of small GTPases and that DENN domains function enzymatically as Rab-specific guanine nucleotide exchange factors. Thus, DENN domain proteins appear to be generalized regulators of Rab function. Study of these proteins will provide new insights into Rab-mediated membrane trafficking pathways.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas rab de Ligação ao GTP
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article