Modulation of TNFSF expression in lymphoid tissue inducer cells by dendritic cells activated with Toll-like receptor ligands.
BMB Rep
; 44(2): 129-34, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-21345313
ABSTRACT
Toll-like receptors (TLRs), which recognize structurally conserved components among pathogens, are mainly expressed by antigen-presenting cells such as dendritic cells (DCs), B cells, and macrophages. Recognition through TLRs triggers innate immune responses and influences antigen-specific adaptive immune responses. Although studies on the expression and functions of TLRs in antigen-presenting cells have been extensively reported, studies in lymphoid tissue inducer (LTi) cells have been limited. In this study, we observed that LTi cells expressed TLR2 and TLR4 mRNA as well as TLR2 protein and upregulated OX40L, CD30L, and TRANCE expression after stimulation with the TLR2 ligand zymosan or TLR4 ligand LPS. The expression of tumor necrosis factor superfamily (TNFSF) members was significantly upregulated when cells were cocultured with DCs, suggesting that upregulated TNFSF expression may contribute to antigen-specific adaptive immune responses.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Zimosan
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Células Dendríticas
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Fatores de Necrose Tumoral
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Receptor 2 Toll-Like
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Receptor 4 Toll-Like
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Tecido Linfoide
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article