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Platelets participate in synovitis via Cox-1-dependent synthesis of prostacyclin independently of microparticle generation.
Boilard, Eric; Larabee, Katherine; Shnayder, Ruslan; Jacobs, Kathleen; Farndale, Richard W; Ware, Jerry; Lee, David M.
Afiliação
  • Boilard E; Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. eric.boilard@crchuq.ulaval.ca
J Immunol ; 186(7): 4361-6, 2011 Apr 01.
Article em En | MEDLINE | ID: mdl-21357261
ABSTRACT
In addition to the well-described role of platelets in thrombosis, a growing body of evidence implicates platelets in diverse inflammatory responses. We recently showed platelets can contribute to the pathophysiology of inflammatory arthritis via IL-1- containing microparticles. In this study, we demonstrate that platelets, and not platelet microparticles, actively contribute to synovitis via production of proinflammatory prostacyclin in an autoimmune arthritis model. Using both genetic and pharmacologic approaches, we establish that paracrine production of prostacyclin proceeds in the absence of cyclooxygenase-2. Furthermore, we also demonstrate that prostacyclin generation can arise via transcellular collaboration between platelets and fibroblast-like synoviocytes. In addition to shedding light on an unappreciated pathway of lipid synthesis in arthritis, we further delineate a novel effector activity by which platelets can contribute to inflammatory disease.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sinovite / Plaquetas / Epoprostenol / Ciclo-Oxigenase 1 / Micropartículas Derivadas de Células Limite: Animals / Humans Idioma: En Ano de publicação: 2011 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sinovite / Plaquetas / Epoprostenol / Ciclo-Oxigenase 1 / Micropartículas Derivadas de Células Limite: Animals / Humans Idioma: En Ano de publicação: 2011 Tipo de documento: Article