[The effect of 1,25(OH)D3 deficiency in the secondary dentin formation and mineralization and caries of the mice].
Hua Xi Kou Qiang Yi Xue Za Zhi
; 28(6): 599-602, 606, 2010 Dec.
Article
em Zh
| MEDLINE
| ID: mdl-21365832
ABSTRACT
OBJECTIVE:
To determine the role of 1,25(OH)2D3 on the secondary dentin formation and mineralization of the mice.METHODS:
The differences of the mandible mineralization between the wild-type and 1-alpha-hydroxylase gene knockout mice at 6 weeks old were assessed by hematoxylin-eosin (HE) staining, immunohistochemistry, alkaline phosphatase (ALP) histochemistry staining.RESULTS:
The ratio of caries were increased significantly, while the secondary dentin was reduced significantly, the deposition of type I collagen and osteocalcin on the secondary dentin of occlusion surface was decreased significantly, but the deposition of the Biglycan on the dentin was increased significantly, the active of ALP on the odontoblasts were reduced significantly in 1-alpha-hydroxylase gene knockout mice compared to that in the wild-type littermates.CONCLUSION:
1,25(OH)2D3 deficiency lead to a defect in the secondary dentin formation and mineralization and caries of the mice.
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Base de dados:
MEDLINE
Assunto principal:
Dentina
/
Dentina Secundária
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2010
Tipo de documento:
Article