Brown adipose tissue responds to cold and adrenergic stimulation by induction of FGF21.
Mol Med
; 17(7-8): 736-40, 2011.
Article
em En
| MEDLINE
| ID: mdl-21373720
ABSTRACT
Fibroblast growth factor-21 (FGF21) is a pleiotropic protein involved in glucose, lipid metabolism and energy homeostasis, with main tissues of expression being the liver and adipose tissue. Brown adipose tissue (BAT) is responsible for cold-induced thermogenesis in rodents. The role of FGF21 in BAT biology has not been investigated. In the present study, wild-type C57BL/6J mice as well as a brown adipocyte cell line were used to explore the potential role of cold exposure and ß3-adrenergic stimulation in the expression of FGF21 in BAT. Our results demonstrate that short-term exposure to cold, as well as ß3-adrenergic stimulation, causes a significant induction of FGF21 mRNA levels in BAT, without a concomitant increase in FGF21 plasma levels. This finding opens new routes for the potential use of pharmaceuticals that could induce FGF21 and, hence, activate BAT thermogenesis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tecido Adiposo Marrom
/
Temperatura Baixa
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Dioxóis
/
Fatores de Crescimento de Fibroblastos
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article