[The progress of TMPRSS2-ETS gene fusions and their mechanism in prostate cancer].
Yi Chuan
; 33(2): 117-22, 2011 Feb.
Article
em Zh
| MEDLINE
| ID: mdl-21377967
ABSTRACT
The gene fusions between transmembrane protease serine 2 (TMPRSS2) and E26 (ETS) transcription factors are present in over 50% of patients with prostate cancer. TMPRSS2-ERG is the most common gene fusion type. The ERG overexpression induced by TMPRSS2-ERG gene fusion contributes to the development of prostate cancer. Both androgen receptor binding and genotoxic stress induce chromosomal proximity and TMPRSS2-ETS gene fusions. TMPRSS2-ERG gene fusion functions as a biomarker for prostate cancer, which can be easily detected in urine. This review focuses on the characteristics, oncogenic and rearranged mechanism, and clinical application of TMPRSS2-ETS gene fusions.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Serina Endopeptidases
/
Proteína Proto-Oncogênica c-ets-1
/
Fusão Gênica
Limite:
Humans
/
Male
Idioma:
Zh
Ano de publicação:
2011
Tipo de documento:
Article