Mechanisms of aneuploidy and its suppression by tumour suppressor proteins.
Swiss Med Wkly
; 141: w13170, 2011.
Article
em En
| MEDLINE
| ID: mdl-21384284
ABSTRACT
Aneuploidy, as a result of numerical changes in chromosome number, was observed in tumours almost a century ago. The molecular mechanisms underlying this phenomenon and their impact on tumour development are still poorly understood. A series of recent observations provide direct linkages between the normal function of tumour suppressor proteins and the suppression of aneuploidy. The prospects that these findings offer for understanding the role of aneuploidy in cancer are discussed in this review.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Supressoras de Tumor
/
Aneuploidia
/
Neoplasias
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article