Myosin light chain kinases and phosphatase in mitosis and cytokinesis.
Arch Biochem Biophys
; 510(2): 76-82, 2011 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-21396909
ABSTRACT
At mitosis, cells undergo drastic alterations in morphology and cytoskeletal organization including cell rounding during prophase, mitotic spindle assembly during prometaphase and metaphase, chromatid segregation in anaphase, and cytokinesis during telophase. It is well established that myosin II is a motor responsible for cytokinesis. Recent reports have indicated that myosin II is also involved in spindle assembly and karyokinesis. In this review, we summarize current understanding of the functions of myosin II in mitosis and cytokinesis of higher eukaryotes, and discuss the roles of possible upstream molecules that control myosin II in these mitotic events.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Quinase de Cadeia Leve de Miosina
/
Fosfatase de Miosina-de-Cadeia-Leve
/
Citocinese
/
Mitose
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article