Design, synthesis and cytotoxic activities of novel ß-amino alcohol derivatives.
Bioorg Med Chem Lett
; 21(8): 2302-4, 2011 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-21397498
Three series of novel ß-amino alcohols possessing an N-anthranyl group have been obtained using tryptophan as the major starting material. These compounds were screened for cytotoxic activity against five human cancer cell lines in vitro by MTT assay, and some of them exhibited potential ability to be anticancer agents. Structure-activity relationship was carefully investigated. Only the compounds possessing small substituents (H or CH(3)) at C-6 position showed the same activity as cisplatin (DDP) did.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Amino Álcoois
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article