[Characterization of hyper-responder patients to cardiac resynchronization therapy]. / Caracterización del paciente hiperrespondedor a la terapia de resincronización cardiaca.

ABSTRACT

BACKGROUND AND OBJECTIVE: To compare clinical and echocardiographic characteristics of the hyper-responders to cardiac resynchronization therapy (CRT) with the rest of patients. PATIENTS AND METHOD: We included 80 consecutive patients treated with CRT. The follow up was 19 (14) months. Patients were considered hyper-responder if they had an ejection fraction of left ventricle (LVEF) ≥ 50% after follow up. RESULTS: Twelve (15%) patients were considered hyper-responders. Their baseline clinical characteristics were similar to the rest except that there were fewer males in the group of hyper-responders. In these patients, basal left ventricle diastolic diameter was 64 (7) mm and the systolic was 55 (6) mm versus 75 (8) mm and 66 (9) mm respectively, p < 0.05. The basal area of mitral regurgitation in the hyper-responders was 3.1 (1.8) cm(2) versus 6.4 (5.5) cm(2), p < 0.05. CONCLUSIONS: Hyper-responder patients are often women with less dilated left ventricle and reduced severity of mitral regurgitation assessed by echocardiography.