Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha.
Immunity
; 34(3): 435-47, 2011 Mar 25.
Article
em En
| MEDLINE
| ID: mdl-21419664
ABSTRACT
Vitamin A and its metabolite, retinoic acid (RA) are implicated in the regulation of immune homeostasis via the peripheral induction of regulatory T cells. Here we showed RA was also required to elicit proinflammatory CD4(+) helper T cell responses to infection and mucosal vaccination. Retinoic acid receptor alpha (RARα) was the critical mediator of these effects. Antagonism of RAR signaling and deficiency in RARα (Rara(-/-)) resulted in a cell-autonomous CD4(+) T cell activation defect, which impaired intermediate signaling events, including calcium mobilization. Altogether, these findings reveal a fundamental role for the RA-RARα axis in the development of both regulatory and inflammatory arms of adaptive immunity and establish nutritional status as a broad regulator of adaptive T cell responses.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tretinoína
/
Linfócitos T CD4-Positivos
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Receptores do Ácido Retinoico
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Imunidade Adaptativa
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article