The effects of bed-rest and countermeasure exercise on the endocrine system in male adults: evidence for immobilization-induced reduction in sex hormone-binding globulin levels.
J Endocrinol Invest
; 35(1): 54-62, 2012 Jan.
Article
em En
| MEDLINE
| ID: mdl-21422800
ABSTRACT
BACKGROUND AND AIM:
There is limited data on the effects of inactivity (prolonged bed-rest) on parameters of endocrine and metabolic function; we therefore aimed to examine changes in these systems during and after prolonged (56- day) bed-rest in male adults. SUBJECTS ANDMETHODS:
Twenty healthy male subjects underwent 8 weeks of strict bed-rest and 12 months of follow-up as part of the Berlin Bed Rest Study. Subjects were randomized to an inactive group or a group that performed resistive vibration exercise (RVE) during bed-rest. All outcome parameters were measured before, during and after bed-rest. These included body composition (by whole body dual X-ray absorptiometry), SHBG, testosterone (T), estradiol (E2), PRL, cortisol (C), TSH and free T3 (FT3).RESULTS:
Serum SHBG levels decreased in inactive subjects but remained unchanged in the RVE group (p<0.001). Serum T concentrations increased during the first 3 weeks of bed-rest in both groups (p<0.0001), while E2 levels sharply rose with re-mobilization (p<0.0001). Serum PRL decreased in the control group but increased in the RVE group (p=0.021). C levels did not change over time (p≥0.10). TSH increased whilst FT3 decreased during bed-rest (p all ≤0.0013).CONCLUSIONS:
Prolonged bed-rest has significant effects on parameters of endocrine and metabolic function, some of which are related to, or counteracted by physical activity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Repouso em Cama
/
Globulina de Ligação a Hormônio Sexual
/
Adaptação Fisiológica
/
Exercício Físico
/
Sistema Endócrino
/
Terapia por Exercício
/
Imobilização
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
Limite:
Adult
/
Humans
/
Male
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article